- UPMC Pinnacle Community General Osteopathic
- UPMC Pinnacle Hanover
- UPMC Pinnacle Harrisburg Hospital
- UPMC Presbyterian
- UPMC Rehabilitation Hospital
- UPMC Shadyside Hospital
- UPMC Somerse
- UPMC Somerset
- UPMC South Side
- UPMC St. Margaret
- UPMC Susquehanna - Soldiers and Sailors Memorial Hospital
- UPMC Susquehanna - Williamsport Regional Medical Center
- UPMC Transplantation Services
- UPMC Wellsboro
- UPMC West Shore
- UPMC Williamsport
- Upper Chesapeake Health
- Upper Connecticut Valley Hospital
- Upper Valley Medical Center
- UPS
- UPS
- Upson Regional Medical Center
- Upstate University Hospital Community Campus
- Uptown Columbus, Inc.
- UR Medicine - Eastman Dental Center
- UR Medicine Noyes Health
- UR Medicine St. James Hospital
- UR Medicine Strong Memorial Hospital
- UR Thompson Hospital (F.F. Thompson Hospital)
- Urban Health Plan, Inc.
- Urban Land Institute
- Urban League of Greater Columbus
- Urban League of Philadelphia
- Urban League of Rhode Island
- Urban Network Organization
- Urban Retreat of Houston
- Urban Wildlife Program
- Urntah County Sheriffs Department
- URS
- URS Corporation
- URS Corporation
- US-ASEAN Business Council, Inc.
- USA 800
- USA Education
- USA Health Children's and Women's Hospital
- USA Health University Hospital
- USA Labs, Inc.
- USA Staffing, Inc.
- USAE
- USANA